Big Pharma Review: a puzzle and business simulator

Big Pharma Review: a puzzle and business simulator


Big Pharma Introduction


Big Pharma is a complex puzzle game and business simulator where you have to create an assembly line that converts raw ingredients into pharmaceutical cures. You will be making a lot of choices and memorizing upgrade paths. You decide which cures to produce, how to setup your factory floor, how to deal with side effects, etc.

Puzzling with Assembly lines in Big Pharma

Big Pharma’s main component is creating assembly lines. Ingredients need to be moved through a series of machines before the finished product can be sold. Optimizing this process can be challenging. Different machines have different shapes and input/output connections that need to be connected by transport belts. Hereby creating a puzzle to maximize space. Some machines take an additional step and will slow your production unless you adjust your layout to take this into account.

It will take a few tries to create neat and compact designs.

Puzzling with concentration levels

Before you can create a layout you first need to decide what machines are required. An Ingredient will have at least one potential cure and one potential side effect, but that still does not tell you what machines to use. This is where the concentration comes into play. Your pharmaceutical will only be effective at the right concentration levels.

For example Satagene Extract could be used to remove warts but could also increase blood pressure. I say could because it all depends on the concentration of the ingredient. In this example Satagene Extract enters the factory at a concentration level of 17. The game will tell us that the active range to remove warts is 11 – 16 and it is most potent at a concentration of 14. So if we create a pill made of Satagene Extract it would not do anything because the effect is not active.

Satagene extract could remove warts, but the concentration level is not within the active range.

To activate the effect we have to lower the concentration to 16 or less. That is where machines come into play! The Dissolver will reduce concentration by 1 and the Ioniser will reduce concentration by 3.  I put the ingredient through a single Ioniniser and the concentration dropped from 17 to 14 (-3), perfect! We now have satagene distillate that can be processed into pills and sold for $99 each.

A machine has lowered the concentration level and activated the ability to remove warts. This creates a nice profit.

However there is a catch. By lowering the concentration we also activated the increase in blood pressure (8-16). So there will be some customers with side effects. There are several strategies to deal with side effects but they will all reduce your profits. I will talk more about those in future chapters.

Upgrading to make advanced cures

The game will become more complex than simply sending an ingredient through one machine and selling it. That is where upgrading comes into play. Once an effect is active it can be upgraded to cure something else entirely.

Moving this product through an Ioniser will make this drug a female contraceptive instead of a warts remover.

In the previous example the ability to remove warts can be upgraded in an Ioniser to become an ingredient for a female contraceptive. A female contraceptive is a tier blue cure and worth much more. Again we have to adjust concentration because our newly upgraded material is strength 11 and the female contraceptive will only activate between a concentrations of 1-6. The good news is that the increased blood pressure is no longer a side effect because that stopped happing below concentration 8. After a series of 9 machines I ended up with the perfect female contraceptive worth $355 ($218 profit).

The pink belts contain the 6 steps required to create a female contraceptive.
The pink belts contain the 6 steps required to create a female contraceptive.

If you thought that was complex then you might not want to hear this: the game does not end at tier blue ingredients. There is also a purple tier that requires you to upgrade an active blue effect. To upgrade to a purple effect you will need to add a catalyst through a mixer. So the chain not only becomes longer, it also becomes more complex. Additionally the catalyst will also have some side effects that you have to deal with.

To summarize the puzzle aspect of the game is a combination of figuring out the right concentration that creates the most potent cure with the least side effects whilst using as little space as possible.

Business simulation

Besides puzzling with layouts and concentrations Big Pharma also has a decent business simulation. All the basics are there. You start with a tiny factory and a limited budget. You can take out a loan but that will make you pay interest. Each machine will have an operating cost meaning additional steps reduce your profit. As soon as something goes through a machine these operating costs will be deducted from your balance. So there is always a tradeoff between making your product better and keeping costs down. The best product does not have to be the most profitable product.

Each step your ingredient takes will be costly. Different machines have different operating costs.
Each step your ingredient takes will be costly. Different machines have different operating costs.

This effect is further strengthened by the in-game economics. When your drug launches it will be rated C. The game will determine the value of your product based on demand, potency and side effects. However, once there have been a few customers the game will know how many people you cured and how many encountered side effects. This can either increase your rating (e.g. A gives a+20% value) or decrease your rating (D- gives -10%).

The game features 11 disease categories that all have 1-3 cures that have a demand that changes over time based on random events, player action and competitors.

Cures screen.
Cures screen.

I mentioned demand because there is an actual market that fluctuates. For example 857 patients could be needing anti-seizure medicine.  At 82% net demand there is already a lower then average price. If you produce even more the saturation will decrease the price further. There is also competition that produces their own cures, often in direct competition with your products.

Explorers and scientists

The game doesn’t end there. You can also hire some staff. Explorers can be send to foreign regions to discover new ingredients. These new ingredients often unlock new cures or provide alternatives with less side effects. Alternatively you can keep them unassigned and they will generate Ingredient Upgrade Points that can be spend to make ingredients cheaper.

Send explorers to some random rainforest to unlock new ingredients or use the to generate upgrade points.
Send explorers to some random rain forest to unlock new ingredients or use the to generate upgrade points.

You can also hire scientists that can be send to active research to unlock new machinery. Alternatively they can be idle and generate Research points. Research points can be spend to reduce operating costs of machinery and expansion.

Unlock new machinery or upgrade existing ones.
Unlock new machinery or upgrade existing ones.

Graphics and Sound

The game is isometric meaning it is two dimensional, but it looks good. At least as far as business simulation games go. Obviously this is no Star Wars Battlefront Directx 12 game. The engine is solid and scales to pretty much any resolution (including 21:9 Ultrawide). It will run on pretty much any machine, even when zoomed out. Information is displayed in different panels or tabs.  A thing that annoyed me were the animations when changing between these tabs. After the 100th time you no longer wish to wait 0.5 seconds for that menu to slide in.

Sound effects are functional and the music is repetitive. Although I doubt you will notice this when you are working on your next complex design.

Big Pharma Missions

Besides the tutorial the game features 7 scenario groups that each group 6 missions of similar difficulty and challenges. In total there are 48 missions to be played. It took me 10 hours to complete the first 9 so there is plenty to do! Additionally the game comes with a free build mode where you can play the game unhindered by restrictions and goals set in some of the scenarios.



Big Pharma is easy to get into but ramps up complexity rather quickly. If you have a good memory and you like puzzling then Big Pharma is a fun game to play. However, if you have a hard time remembering 3 or more components than you may find this game incredibly frustrating. I can recommend this game to anyone that enjoys puzzles. For business sim fanatics it will depend on your willingness to micromanage designs.